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Yet, the mechanisms tumor cells use to control metastatic niche formation are not fully understood. Here we report that in the lung metastatic niche, high-metastatic hepatocellular carcinoma HCC cells exhibit a greater capacity to convert normal fibroblasts to cancer-associated fibroblasts CAFs than low-metastatic HCC cells. Clinical data show high serum exosomal miRp levels correlate with lung metastasis in HCC patients. These results demonstrate intercellular crosstalk between tumor cells and fibroblasts is mediated by tumor-derived exosomes that control lung metastasis of HCC, providing potential targets for prevention and treatment of cancer metastasis. Introduction Lung metastasis is the most frequent distant invasive progression and one of the main causes of cancer-related deaths in hepatocellular carcinoma HCC 1 , 2. The process involves several steps driven by intercellular communications among various cells in the tumor microenvironment, including tumor cells and stromal cells 3 , 4.
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Posted on Last edited by Raphael; 19th March at Una Piccola Franthe.
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Email With his closely cropped hair, ever burning cigarette, and trademark round eyeglasses, Zhang Xiaogang has become the face of Chinese art, an unlikely rock-star figure at the head of a mania sweeping auction houses from Beijing to New York. In the mids, his work was banned in his home country. Photograph by Jonathan Becker.

All сomments (8)

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